High tumor mutation burden and DNA repair gene mutations

Introduction Anaplastic lymphoma kinase (ALK)‑fusion genes represent a small but important part of oncogenic driver mutations in NSCLC, accounting for approximately 3%‑7% of all cases worldwide.1,2 Small molecule tyrosine kinase…

Gwangju Institute of Science and Technology Scientists Unravel the Inner Workings of DNA Repair Enzymes

GWANGJU, South Korea, September 14, 2021 / PRNewswire / – A new review by researchers at the Gwangju Institute of Science and Technological know-how in the Republic of Korea has…

Correction for Morozko et al., PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease

NEUROSCIENCE Correction for “PIAS1 modulates striatal transcription, DNA harm repair service and SUMOylation relevant to Huntington’s ailment”, by Eva L. Morozko, Charlene Smith-Geater, Alejandro Mas Monteys, Subrata Pradhan, Ryan G.…

Novartis partner Artios bags megaround to drive clinical work on DNA damage repair factors – Endpoints News

5 months right after Bob Bradway, CEO of Amgen, stepped down to the M&A table and bought Five Primary for $ 1.9 billion, adopted by the scaled-down Rodeo acquisition, he…

Impact of DNA damage repair defects on response to PSMA radioligand therapy in metastatic castration-resistant prostate cancer

This article was originally released right here Prostate most cancers prostate ailment. 2021 July 12th doi: 10.1038 / s41391-021-00424-2. On the web before printing. Summary Purpose: Prostate Unique Membrane Antigen…

Sharing shears: Conserved protein phase prompts molecular DNA scissors for DNA restore

IMAGE: CtIP / Ctp1 stimulates the endonuclease activity of the MRN complex, which not only polishes “dirty” ends of DNA breaks, but also promotes the precise repair of DNA breaks…

When the injury is finished – how ICR scientists deal with DNA injury restore

Image: DNA double helix (computer visualization). Photo credit: Arek Socha via Pixabay DNA damage is the leading cause of cancer. As you read this, many of your cells are producing…