Lamkanfi, M. et al. Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol. Cell. Proteomics 7, 2350–2363 (2008).
Google Scholar
Sellin, M. E. et al. Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa. Cell Host Microbe 16, 237–248 (2014).
Google Scholar
Rauch, I. et al. NAIP-NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of caspase-1 and -8. Immunity 46, 649–659 (2017).
Google Scholar
Kuida, K. et al. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384, 368–372 (1996).
Google Scholar
Lakhani, S. A. et al. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311, 847–851 (2006).
Google Scholar
Wu, C. et al. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol. 10, R130 (2009).
Google Scholar
Reikvam, D. H. et al. Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression. PLoS One 6, e17996 (2011).
Google Scholar
Marchiando, A. M. et al. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology 140, 1208–1218 (2011).
Google Scholar
Nozaki, K., Li, L. & Miao, E. A. Innate sensors trigger regulated cell death to combat intracellular infection. Annu. Rev. Immunol. 40, 469–498 (2022).
Google Scholar
Andrews, N. W., Almeida, P. E. & Corrotte, M. Damage control: cellular mechanisms of plasma membrane repair. Trends Cell Biol. 24, 734–742 (2014).
Google Scholar
Edelmann, B. et al. Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes. EMBO J. 30, 379–394 (2011).
Google Scholar
Ferlinz, K. et al. Functional characterization of the N-glycosylation sites of human acid sphingomyelinase by site-directed mutagenesis. Eur. J. Biochem. 243, 511–517 (1997).
Google Scholar
Andrews, N. W., Corrotte, M. & Castro-Gomes, T. Above the fray: surface remodeling by secreted lysosomal enzymes leads to endocytosis-mediated plasma membrane repair. Semin. Cell Dev. Biol. 45, 10–17 (2015).
Google Scholar
Llacuna, L., Marí, M., Garcia-Ruiz, C., Fernandez-Checa, J. C. & Morales, A. Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. Hepatology 44, 561–572 (2006).
Google Scholar
Müller, A. J. et al. The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation. Cell Host Microbe 6, 125–136 (2009).
Google Scholar
Quan, L. T. et al. Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proc. Natl Acad. Sci. USA 93, 1972–1976 (1996).
Google Scholar
Darmon, A. J., Nicholson, D. W. & Bleackley, R. C. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature 377, 446–448 (1995).
Google Scholar
Chinnaiyan, A. M. et al. Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3. Curr. Biol. 6, 897–899 (1996).
Google Scholar
Gu, Y. et al. Processing and activation of CMH-1 by granzyme B. J. Biol. Chem. 271, 10816–10820 (1996).
Google Scholar
Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J. & Dixit, V. M. The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J. Biol. Chem. 271, 16443–16446 (1996).
Google Scholar
Jorgensen, I., Rayamajhi, M. & Miao, E. A. Programmed cell death as a defence against infection. Nat. Rev. Immunol. 17, 151–164 (2017).
Google Scholar
Batista, J. H. & da Silva Neto, J. F. Chromobacterium violaceum pathogenicity: updates and insights from genome sequencing of novel Chromobacterium species. Front. Microbiol. 8, 2213 (2017).
Maltez, V. I. et al. Inflammasomes coordinate pyroptosis and natural killer cell cytotoxicity to clear infection by a ubiquitous environmental bacterium. Immunity 43, 987–997 (2015).
Google Scholar
Rongvaux, A. et al. Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell 159, 1563–1577 (2014).
Google Scholar
McArthur, K. et al. BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science 359, eaao6047 (2018).
Google Scholar
Sauer, J. D. et al. Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity. Proc. Natl Acad. Sci. USA 108, 12419–12424 (2011).
Google Scholar
Warren, S. E. et al. Generation of a Listeria vaccine strain by enhanced caspase-1 activation. Eur. J. Immunol. 41, 1934–1940 (2011).
Google Scholar
Clark, S. E., Schmidt, R. L., McDermott, D. S. & Lenz, L. L. A Batf3/Nlrp3/IL-18 axis promotes natural killer cell IL-10 production during Listeria monocytogenes infection. Cell Rep. 23, 2582–2594 (2018).
Google Scholar
Kägi, D., Ledermann, B., Bürki, K., Hengartner, H. & Zinkernagel, R. M. CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity. Eur. J. Immunol. 24, 3068–3072 (1994).
Google Scholar
Harty, J. T., Lenz, L. L. & Bevan, M. J. Primary and secondary immune responses to Listeria monocytogenes. Curr. Opin. Immunol. 8, 526–530 (1996).
Google Scholar
Hsu, K. M., Pratt, J. R., Akers, W. J., Achilefu, S. I. & Yokoyama, W. M. Murine cytomegalovirus displays selective infection of cells within hours after systemic administration. J. Gen. Virol. 90, 33–43 (2009).
Google Scholar
Kägi, D. et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369, 31–37 (1994).
Google Scholar
Rühl, S. et al. ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation. Science 362, 956–960 (2018).
Google Scholar
Gong, Y. N. et al. ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences. Cell 169, 286–300 (2017).
Google Scholar
Boucher, D. et al. Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. J. Exp. Med. 215, 827–840 (2018).
Google Scholar
Jost, P. J. et al. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature 460, 1035–1039 (2009).
Google Scholar
Halle, S. et al. In vivo killing capacity of cytotoxic T cells is limited and involves dynamic interactions and T cell cooperativity. Immunity 44, 233–245 (2016).
Google Scholar
Keefe, D. et al. Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity 23, 249–262 (2005).
Google Scholar
Thiery, J. et al. Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood 115, 1582–1593 (2010).
Google Scholar
Jorgensen, I., Zhang, Y., Krantz, B. A. & Miao, E. A. Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis. J. Exp. Med. 213, 2113–2128 (2016).
Google Scholar
Mariathasan, S. et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430, 213–218 (2004).
Google Scholar
Kuida, K. et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267, 2000–2003 (1995).
Google Scholar
Zheng, T. S., Hunot, S., Kuida, K. & Flavell, R. A. Caspase knockouts: matters of life and death. Cell Death Differ. 6, 1043–1053 (1999).
Google Scholar
Miao, E. A. et al. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat. Immunol. 11, 1136–1142 (2010).
Google Scholar
Wheat, R. L., Clark, P. Y. & Brown, M. G. Quantitative measurement of infectious murine cytomegalovirus genomes in real-time PCR. J. Virol. Methods 112, 107–113 (2003).
Google Scholar
Barthel, M. et al. Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host. Infect. Immun. 71, 2839–2858 (2003).
Google Scholar
Butler, S. L. et al. The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1. Lab. Invest. 88, 78–88 (2008).
Google Scholar
Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262–265 (2009).
Google Scholar
Miyoshi, H. & Stappenbeck, T. S. In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Nat. Protoc. 8, 2471–2482 (2013).
Google Scholar
von Moltke, J. et al. Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature 490, 107–111 (2012).
Google Scholar
Gregory, S. H., Jiang, X. & Wing, E. J. Lymphokine-activated killer cells lyse Listeria-infected hepatocytes and produce elevated quantities of interferon-γ. J. Infect. Dis. 174, 1073–1079 (1996).
Google Scholar
Badovinac, V. P. & Harty, J. T. Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-γ. J. Immunol. 164, 6444–6452 (2000).
Google Scholar
Ahmed, R., Salmi, A., Butler, L. D., Chiller, J. M. & Oldstone, M. B. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 160, 521–540 (1984).
Google Scholar
Cooper, H. S., Murthy, S. N., Shah, R. S. & Sedergran, D. J. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab. Invest. 69, 238–249 (1993).
Google Scholar
